Synthesis of Small Molecule Inhibitors Using "Click Chemistry" for the Inhibition of Breast Cancer Metastasis
Faculty Mentor Information
Dr. Don Warner (Mentor), Boise State University
Abstract
Metastasis of breast cancer plays a crucial role in patient survival rates, plummeting from 99% down to 27% once the cancer spreads. It has been associated with a particular inflammatory cytokine (IC), which we hypothesize can be disrupted via a small molecule inhibitor (SMI). A virtual screening of 1.65 million SMI analogs identified 26 promising SMIs; of which SMI-8, 10, and 26 were found to effectively inhibit the targeted IC. SMI-26 has gone through several design iterations, during which specific regions of the drug were optimized. Currently, a new library of analogs is being synthesized. Specifically, a new kind of synthesis using “Click Chemistry” through triazole is being used to make new analogs. The results of the research will be discussed in the following presentation.
Synthesis of Small Molecule Inhibitors Using "Click Chemistry" for the Inhibition of Breast Cancer Metastasis
Metastasis of breast cancer plays a crucial role in patient survival rates, plummeting from 99% down to 27% once the cancer spreads. It has been associated with a particular inflammatory cytokine (IC), which we hypothesize can be disrupted via a small molecule inhibitor (SMI). A virtual screening of 1.65 million SMI analogs identified 26 promising SMIs; of which SMI-8, 10, and 26 were found to effectively inhibit the targeted IC. SMI-26 has gone through several design iterations, during which specific regions of the drug were optimized. Currently, a new library of analogs is being synthesized. Specifically, a new kind of synthesis using “Click Chemistry” through triazole is being used to make new analogs. The results of the research will be discussed in the following presentation.