Synthesis of Small Molecule Inhibitors Using "Click Chemistry" for the Inhibition of Breast Cancer Metastasis

Faculty Mentor Information

Dr. Don Warner (Mentor), Boise State University

Presentation Date

7-2024

Abstract

Metastasis of breast cancer plays a crucial role in patient survival rates, plummeting from 99% down to 27% once the cancer spreads. It has been associated with a particular inflammatory cytokine (IC), which we hypothesize can be disrupted via a small molecule inhibitor (SMI). A virtual screening of 1.65 million SMI analogs identified 26 promising SMIs; of which SMI-8, 10, and 26 were found to effectively inhibit the targeted IC. SMI-26 has gone through several design iterations, during which specific regions of the drug were optimized. Currently, a new library of analogs is being synthesized. Specifically, a new kind of synthesis using “Click Chemistry” through triazole is being used to make new analogs. The results of the research will be discussed in the following presentation.

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Synthesis of Small Molecule Inhibitors Using "Click Chemistry" for the Inhibition of Breast Cancer Metastasis

Metastasis of breast cancer plays a crucial role in patient survival rates, plummeting from 99% down to 27% once the cancer spreads. It has been associated with a particular inflammatory cytokine (IC), which we hypothesize can be disrupted via a small molecule inhibitor (SMI). A virtual screening of 1.65 million SMI analogs identified 26 promising SMIs; of which SMI-8, 10, and 26 were found to effectively inhibit the targeted IC. SMI-26 has gone through several design iterations, during which specific regions of the drug were optimized. Currently, a new library of analogs is being synthesized. Specifically, a new kind of synthesis using “Click Chemistry” through triazole is being used to make new analogs. The results of the research will be discussed in the following presentation.