Synthesis of Small Molecule Inhibitors by Click Chemistry to Combat Breast Cancer Metastasis
Faculty Mentor Information
Dr. Don Warner (Mentor), Boise State University
Abstract
266,000 thousand women per year are diagnosed with breast cancer, and of them between 20 to thirty percent will metastasize. When cancer metastasizes, it travels from its point of origin to other organs in the body dropping five year survival rates from 99% to 29% when it does. Previous work has shown an inflammatory cytokine is a promoter of cancer metastasis when over expressed. This is achieved via the JAK/STAT pathway, which allows small molecule inhibitors to interfere with the IC binding to its receptors. Previous work on SMI 26 showed promise, but the methods by which the SMI and its analogs were produced resulted in low water solubility. By the use of click chemistry, we aim to solve this issue, and create a simpler reaction path to the SMI and its derivatives. Three azide compounds were created with different functional groups attached, then via click chemistry linked to the core of SMI 26. The theoretical binding values were then analyzed and we found that [data to be analyzed].
Synthesis of Small Molecule Inhibitors by Click Chemistry to Combat Breast Cancer Metastasis
266,000 thousand women per year are diagnosed with breast cancer, and of them between 20 to thirty percent will metastasize. When cancer metastasizes, it travels from its point of origin to other organs in the body dropping five year survival rates from 99% to 29% when it does. Previous work has shown an inflammatory cytokine is a promoter of cancer metastasis when over expressed. This is achieved via the JAK/STAT pathway, which allows small molecule inhibitors to interfere with the IC binding to its receptors. Previous work on SMI 26 showed promise, but the methods by which the SMI and its analogs were produced resulted in low water solubility. By the use of click chemistry, we aim to solve this issue, and create a simpler reaction path to the SMI and its derivatives. Three azide compounds were created with different functional groups attached, then via click chemistry linked to the core of SMI 26. The theoretical binding values were then analyzed and we found that [data to be analyzed].