Identification and Quantification of Sesquiterpene Lactones (SLs) in Sagebrush (Artemisia tridentata) and Its Chemical Modification
Additional Funding Sources
The project described was supported by the Ronald E. McNair Post-Baccalaureate Achievement Program through the U.S. Department of Education under Award No. P217A170169 and a student grant from the Idaho State University Office of Undergraduate Research.
Presentation Date
7-2020
Abstract
Artemisia (sagebrush) an aromatic shrub native to a variety of habitats and climates, which range from cold desert conditions to the intermountain states of United States. Artemisia is a medicinal shrub due to its capacity to alleviate human afflictions such as internal bleeding, headaches, external infections, and respiratory malfunctions. Terpenoids especially sesquiterpene lactones (SLs), phenolic acids, flavonoids, sterols, fatty acids, lignans and acetylenes constitute major classes of phytochemicals in Artemisia tridentate. SLs are fifteen carbon terpenes formed from incorporation of three isoprene units, followed by cyclization and oxidative transformation to make a cis or trans-fused lactone. The ๐พ-lactone ring, usually with a ๐ผ-methylene group, is a significant characteristic of SLs. Their molecular structure may present hydroxyls, esterified hydroxyls, or epoxide groups. Some SLs occur in glycosylated form, and a few contain halogen or sulfur atoms. A number of SLs in cancer clinical trials have properties that enable them to target tumor and cancer stem cells while sparing normal ones.
Identification and Quantification of Sesquiterpene Lactones (SLs) in Sagebrush (Artemisia tridentata) and Its Chemical Modification
Artemisia (sagebrush) an aromatic shrub native to a variety of habitats and climates, which range from cold desert conditions to the intermountain states of United States. Artemisia is a medicinal shrub due to its capacity to alleviate human afflictions such as internal bleeding, headaches, external infections, and respiratory malfunctions. Terpenoids especially sesquiterpene lactones (SLs), phenolic acids, flavonoids, sterols, fatty acids, lignans and acetylenes constitute major classes of phytochemicals in Artemisia tridentate. SLs are fifteen carbon terpenes formed from incorporation of three isoprene units, followed by cyclization and oxidative transformation to make a cis or trans-fused lactone. The ๐พ-lactone ring, usually with a ๐ผ-methylene group, is a significant characteristic of SLs. Their molecular structure may present hydroxyls, esterified hydroxyls, or epoxide groups. Some SLs occur in glycosylated form, and a few contain halogen or sulfur atoms. A number of SLs in cancer clinical trials have properties that enable them to target tumor and cancer stem cells while sparing normal ones.