Document Type
Article
Publication Date
10-2023
Abstract
Background: Farnesol (FOL) prevents the onset of experimental autoimmune encephalomyelitis (EAE), a murine model of multiple sclerosis (MS).
Objective: We examined the transcriptomic profile of the brains of EAE mice treated with daily oral FOL using next-generation sequencing (RNA-seq).
Methods: Transcriptomics from whole brains of treated and untreated EAE mice at the peak of EAE was performed.
Results: EAE-induced mice, compared to naïve, healthy mice, overall showed increased expression in pathways for immune response, as well as an increased cytokine signaling pathway, with downregulation of cellular stress proteins. FOL downregulates pro-inflammatory pathways and attenuates the immune response in EAE. FOL downregulated the expression of genes involved in misfolded protein response, MAPK activation/signaling, and pro-inflammatory response.
Conclusion: This study provides insight into the molecular impact of FOL in the brain and identifies potential therapeutic targets of the isoprenoid pathway in MS patients.
Copyright Statement
This is an author-produced, peer-reviewed version of this article. © 2023, Elsevier. Licensed under the Creative Commons Attribution-NonCommercial-No Derivative Works 4.0 International license. The final, definitive version of this document can be found online at Clinical Immunology, https://doi.org/10.1016/j.clim.2023.109752
Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial-No Derivative Works 4.0 International License.
Publication Information
Doyle, William J.; Walters, Dana; Shi, Xutong; Hoffman, Kristina; Magori, Krisztian; Roullet, Jean-Baptiste; and Ochoa-Repáraz, Javier. (2023). "Farnesol Brain Transcriptomics in CNS Inflammatory Demyelination". Clinical Immunology, 255, 109752. https://doi.org/10.1016/j.clim.2023.109752