On-Chip Active Pulse-Clamp Stimulation (APCS) for Rapid Recovery, Charge-Balanced Neural Stimulation
Publication Date
5-2024
Date of Final Oral Examination (Defense)
3-1-2024
Type of Culminating Activity
Dissertation
Degree Title
Doctor of Philosophy in Electrical and Computer Engineering
Department Filter
Electrical and Computer Engineering
Department
Electrical and Computer Engineering
Supervisory Committee Chair
Benjamin Johnson, Ph.D.
Supervisory Committee Member
Kurtis Cantley, Ph.D.
Supervisory Committee Member
Nader Rafla, Ph.D.
Abstract
Neurostimulations are widely utilized to modulate brains and nervous systems functions for therapeutic purposes. Traditional neurostimulation involves applying a direct current delivered to the excitable tissues to elicit neural response. There is a growing demand for a robust, rapid stimulation system that ensures chronic safety through charge balancing in vivo. This dissertation is a compilation of previously published works, detailing various board-level stimulators, an innovative on-chip stimulation technique, and a distributed modelling method.
Chapter one introduces MEDUSA, a cost-effective, multi-functional neurostimulation system capable of achieving multi-channel, arbitrary stimulation for neuroscience research.
Chapter two delves into a scripted distributed model framework facilitating the co-design of neural recording frontends and stimulators, crucial for close-loop application necessitating electrode interface characterization.
Chapter three focuses on a small, low-cost, wireless neurostimulator designed for rodent deep brain stimulation applications.
Chapter four serves as an introduction to the Active Pulse-Clamp Stimulation (APCS), presenting the linear APCS theory and a validated system proficient in rapid electrode interface recovery while maintaining charge balancing.
In Chapter five, an on-chip APCS system is introduced, integrating both linear APCS and slewing APCS mode. This innovative system employs the slewing mode for swift charge recovery and ensures charge balancing through the linear mode.
DOI
https://doi.org/10.18122/td.2223.boisestate
Recommended Citation
Tala, F. N. U., "On-Chip Active Pulse-Clamp Stimulation (APCS) for Rapid Recovery, Charge-Balanced Neural Stimulation" (2024). Boise State University Theses and Dissertations. 2223.
https://doi.org/10.18122/td.2223.boisestate
