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Publication Date

12-2019

Date of Final Oral Examination (Defense)

10-29-2019

Type of Culminating Activity

Dissertation - Boise State University Access Only

Degree Title

Doctor of Philosophy in Biomolecular Sciences

Department

Biology

Major Advisor

Eric J. Hayden, Ph.D.

Advisor

Matthew Ferguson, Ph.D.

Advisor

Adam Colson, Ph.D.

Abstract

Fluorogenic aptamers are emerging as useful molecular tools to track RNA molecules in cells and as a platform for fluorescent biosensors. The recently developed RNA Mango-I fluorogenic aptamer has a promising combination of tight binding and bright signal. However, the structure of RNA Mango limits its ability to be used for biosensor engineering. We have developed a flexible design platform for RNA Mango I that has been used to develop a novel biosensor. This process can be utilized for continual adaptation of the RNA Mango I platform into numerous new biosensors.

DOI

10.18122/td/1627/boisestate

Available for download on Sunday, January 09, 2022

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