Document Type
Contribution to Books
Publication Date
2-1-2012
Abstract
Atomic force microscopy (AFM) is one of the most important tools that lead current nanoscience and nanotechnology in many diverse areas including physics, chemistry, material engineering, and nano-biology. The current AFM technique has been routinely applied to forced unbinding processes of biomolecular complexes such as antibody-antigen binding, ligand-receptor pairs, protein unfolding, DNA unbinding, and RNA unfolding studies (Butt et al., 2005; Fritz & Anselmetti, 1997; Schumakovitch et al., 2002). AFMs have also been applied to intermolecular friction studies (Carpick et al., 1997; Colchero et al., 1996; Fernandez-Torres et al., 2003; Goddenhenrich et al., 1994; Goertz et al., 2007; B.I. Kim et al., 2001; Major et al., 2006). These previous techniques of measuring friction employed a lateral modulation of the sample relative to the cantilever as a means to measure normal force and friction force at the same time (Burns et al., 1999a; Carpick et al., 1997; Colchero et al., 1996; Goddenhenrich et al., 1994; Goertz et al., 2007; Major et al., 2006).
Copyright Statement
This document was originally published by InTech in Molecular Interaction. This work is provided under a Creative Commons Attribution-NonCommercial-ShareAlike 3.0 license. Details regarding the use of this work can be found at: http://creativecommons.org/licenses/by-nc-sa/3.0/legalcode. http://www.intechopen.com/
Publication Information
Kim, Byung I.. (2012). "Cantilever-Based Optical Interfacial Force Microscopy". Molecular Interaction, 125-144.