Magnetic Shape Memory Micropump for Submicroliter Intracranial Drug Delivery in Rats

Authors

Sam Barker, Boise State University
Eric Rhoads, Boise State University
Paul Lindquist, Boise State UniversityFollow
Martin Vreugdenhil, University of Birmingham
Peter Müllner, Boise State UniversityFollow

Document Type

Article

Publication Date

12-2016

Abstract

Point-of-care diagnostic devices, micrototal analysis (μTAS) systems, lab-on-a-chip development, and biomedical research rely heavily upon microfluidic management and innovative micropump design. Here, we describe the design and prototype deployment of a magnetic shape memory (MSM) micropump capable of submicroliter per minute flow rates. The pump contains no valves or moving parts in the fluid channel and is capable of bidirectional fluid transport. This pump was employed as the mechanism to deliver small intracranial dosages of ketamine and tetrodotoxin (TTX) at 0.33 μl/min during in vivo electrophysiological recordings in anesthetized rats, performing to required specifications.

Publication Information

Barker, Sam; Rhoads, Eric; Lindquist, Paul; Vreugdenhil, Martin; and Müllner, Peter. (2016). "Magnetic Shape Memory Micropump for Submicroliter Intracranial Drug Delivery in Rats". Journal of Medical Devices, 10(4), 041009-1 - 041009-6. https://doi.org/10.1115/1.4034576