Document Type
Conference Proceeding
Publication Date
1-21-2011
Abstract
The potential for inferring the presence of cancer by the detection of miRNA in human blood has motivated research into the design and operation of DNA-based chemical amplifiers that can operate in bodily fluids. As a first step toward this goal, we have tested the operation of a DNA-based autocatalytic network in human serum and mouse serum. With the addition of sodium dodecyl sulfate to prevent degradation by nuclease activity, the network was found to operate successfully with both DNA and RNA catalysts.
Copyright Statement
This is an author-produced, peer-reviewed version of this article. The final publication is available at www.springerlink.com. Copyright restrictions may apply. DOI: 10.1007/978-3-642-18305-8
Publication Information
Graugnard, Elton; Cox, Amber; Lee, Jeunghoon; Jorcyk, Cheryl; Yurke, Bernard; and Hughes, William L.. (2011). "Operation of a DNA-Based Autocatalytic Network in Serum". DNA'10 Proceedings of the 16th International Conference on DNA Computing and Molecular Programming, 83-88. https://doi.org/10.1007/978-3-642-18305-8