How LIV Could Change the Fate of Chemotherapy Patients at Risk for Osteological Deficiencies
Faculty Mentor Information
Dr. Anamaria Zavala (Mentor), Boise State University
Abstract
Common cancer treatments drugs, such as platinum-based chemotherapy agents, significantly impact the deposition and overall composition of a patient’s bone health. In an attempt to mitigate cellular senescence from the toxins in healthy cells, we have utilized low- intensity vibrations (LIV) that mechanically stimulate osteoblastic mesenchymal stem cells (MSC), with the objective of promoting a more resistant and offensive extracellular matrix (ECM) that has an increased ability to repair damages. This approach raises the potential of increasing dosage protocols in order to more efficiently treat cancers. MSCs were damaged with cisplatin to mimic chemotherapy regimes. They were then differentiated, while the ECM was collected. Multiple assays and qualifications were performed to quantify the repair and size of osteoblast nodules. It was found that LIV does have a positive impact on the extracellular matrix and repair of osteoblasts. Additionally, it was found that differentiated MSCs exposed to cisplatin seem to present greater osteoblast deposition due to the increased stress response compared to the undamaged cells.
How LIV Could Change the Fate of Chemotherapy Patients at Risk for Osteological Deficiencies
Common cancer treatments drugs, such as platinum-based chemotherapy agents, significantly impact the deposition and overall composition of a patient’s bone health. In an attempt to mitigate cellular senescence from the toxins in healthy cells, we have utilized low- intensity vibrations (LIV) that mechanically stimulate osteoblastic mesenchymal stem cells (MSC), with the objective of promoting a more resistant and offensive extracellular matrix (ECM) that has an increased ability to repair damages. This approach raises the potential of increasing dosage protocols in order to more efficiently treat cancers. MSCs were damaged with cisplatin to mimic chemotherapy regimes. They were then differentiated, while the ECM was collected. Multiple assays and qualifications were performed to quantify the repair and size of osteoblast nodules. It was found that LIV does have a positive impact on the extracellular matrix and repair of osteoblasts. Additionally, it was found that differentiated MSCs exposed to cisplatin seem to present greater osteoblast deposition due to the increased stress response compared to the undamaged cells.