Lack of the DNA Repair Protein Blm During Drosophila Embryonic Development Impacts Metabolic Function

Additional Funding Sources

This project is supported by a 2021-2022 STEM Undergraduate Research Grant from the Higher Education Research Council and an Institutional Development Award (IDeA) from the National Institute of General Medical Sciences of the National Institutes of Health under Grant No. P20GM103408.

Presentation Date

7-2022

Abstract

Blm DNA helicase is essential during early development in Drosophila. Most embryos from Blm mutant mothers do not survive due to a lack of maternally provided Blm products. We hypothesize that the small number of progeny that do survive this Blm-deficiency during early development will have experienced DNA damage that impacts long-term metabolic function. This will be assessed by measuring adult body weight and triglyceride levels in progeny that develop with or without maternal Blm.

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Lack of the DNA Repair Protein Blm During Drosophila Embryonic Development Impacts Metabolic Function

Blm DNA helicase is essential during early development in Drosophila. Most embryos from Blm mutant mothers do not survive due to a lack of maternally provided Blm products. We hypothesize that the small number of progeny that do survive this Blm-deficiency during early development will have experienced DNA damage that impacts long-term metabolic function. This will be assessed by measuring adult body weight and triglyceride levels in progeny that develop with or without maternal Blm.