Additional Funding Sources
The project described was supported by the Center of Excellence in Biomedical Research through the Institutional Development Award (IDeA) from the National Institute of General Medical Sciences of the National Institutes of Health under Grant Nos. P20GM109095 and P20GM103408 and the National Science Foundation S-STEM Gateway Scholarships in Biological Sciences under Grant Award No. DUE-1644233.
Abstract
S. aureus is the primary cause of mastitis in cows. Mastitis is an infection of the mammary gland in the udder, which can be devastating for the animal and milk production. It is the most economically significant disease in the dairy industry. Creating a vaccine for S. aureus in dairy animals could reduce the number of antibiotics administered and prevent millions in economic losses annually. Cholera toxin can be used as an effective vaccine by replacing its toxic subunit with S. aureus antigens. This vaccine has the potential to induce antigen-specific immune responses that prevent the establishment of infection and mastitis development.
Using Cholera Toxin Chimera for Staphylococcus aureus Vaccine
S. aureus is the primary cause of mastitis in cows. Mastitis is an infection of the mammary gland in the udder, which can be devastating for the animal and milk production. It is the most economically significant disease in the dairy industry. Creating a vaccine for S. aureus in dairy animals could reduce the number of antibiotics administered and prevent millions in economic losses annually. Cholera toxin can be used as an effective vaccine by replacing its toxic subunit with S. aureus antigens. This vaccine has the potential to induce antigen-specific immune responses that prevent the establishment of infection and mastitis development.