The Effect of Mutation on Age-Related Changes in Protein Aggregation in Daphnia magna
Faculty Mentor Information
Dr. Leigh C. Latta
Presentation Date
7-2017
Abstract
Protein aggregates are associated with various age-related pathologies of the nervous system, such as Huntington’s disease and Alzheimer’s disease in humans. This research examines the extent to which spontaneous mutations may exacerbate age-related changes in the accumulation of protein aggregates in the model organism Daphnia magna. Protein aggregates in young and old mutant and non-mutant lines of Daphnia are quantified fluorometrically, and then the age-related patterns of protein aggregation are compared between the four groups.
The Effect of Mutation on Age-Related Changes in Protein Aggregation in Daphnia magna
Protein aggregates are associated with various age-related pathologies of the nervous system, such as Huntington’s disease and Alzheimer’s disease in humans. This research examines the extent to which spontaneous mutations may exacerbate age-related changes in the accumulation of protein aggregates in the model organism Daphnia magna. Protein aggregates in young and old mutant and non-mutant lines of Daphnia are quantified fluorometrically, and then the age-related patterns of protein aggregation are compared between the four groups.