2019 Graduate Student Showcase
 

Title of Submission

Generation of Lead SMW Fortilin Inhibitors That Bind and Destroy Fortilin in the Cell

Degree Program

Biomolecular Sciences, PhD

Major Advisor Name

Owen McDougal

Type of Submission

Scholarly Poster

Judging Session

9am - 10:30am - Judging Session #1

Abstract

Translationally controlled tumor protein, also known as fortilin, is a 172 amino acid cytosolic shuttle protein of 20 kDa that prevents apoptosis through various mechanisms and accelerates atherosclerosis by allowing macrophage propagation. The goal of this research is to express 15N/13C labeled fortilin in E. coli cells and use novel small molecular weight (SMW) inhibitors that are derived from previously determined fortilin inhibiting small molecular weight compounds (FISCs) and evaluate their potency by determining their ability to bind and inhibit fortilin using a combination of computational methods, nuclear magnetic resonance (NMR) and surface plasmon resonance (SPR).

Funding Information

ROI Grant 1R01HL117247-01

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