In-Vitro Validated Methods for Encoding Digital Data in Deoxyribonucleic Acid (DNA)

Authors

Golam Md Mortuza, Boise State University
Jorge Guerrero, North Carolina A&T State University
Shoshanna Llewellyn, Boise State University
Michael D. Tobiason, Boise State University
George D. Dickinson, Boise State University
William L. Hughes, University of British Columbia
Reza Zadegan, North Carolina A&T State University
Tim Andersen, Boise State UniversityFollow

Document Type

Article

Publication Date

4-21-2023

Abstract

Deoxyribonucleic acid (DNA) is emerging as an alternative archival memory technology. Recent advancements in DNA synthesis and sequencing have both increased the capacity and decreased the cost of storing information in de novo synthesized DNA pools. In this survey, we review methods for translating digital data to and/or from DNA molecules. An emphasis is placed on methods which have been validated by storing and retrieving real-world data via in-vitro experiments.

Comments

Golam Md Mortuza and Jorge Guerrero have contributed equally to this work.

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

Publication Information

Mortuza, Golam Md; Guerrero, Jorge; Llewellyn, Shoshanna; Tobiason, Michael D.; Dickinson, George D.; Hughes, William L.; Zadegan, Reza; and Andersen, Tim. (2023). "In-Vitro Validated Methods for Encoding Digital Data in Deoxyribonucleic Acid (DNA)". BMC Bioinformatics, 24, 160. https://doi.org/10.1186/s12859-023-05264-6