Carrier Protein Mediated Cargo Sensing in Quorum Signal Synthases
Acyl-homoserine lactone synthases make specific AHL quorum sensing signals to aid virulence in Gram-negative bacteria. Here, we use solution NMR spectroscopy to demonstrate that the carrier protein–enzyme interface accurately reveals substrate recognition mechanisms in two quorum signal synthases.
Fischer, Patrick D.; Chowdhury, Abu Sayeed; Bartholow, Thomas; Basu, Shibani; Baggs, Eric; Cox, Huel S., III; . . . and Arthanari, Haribabu. (2023). "Carrier Protein Mediated Cargo Sensing in Quorum Signal Synthases". Chemical Communications, 59(8), 1014-1017. https://doi.org/10.1039/D2CC03551K