The Effect of Mutation on Age-Related Changes in Protein Aggregation in Daphnia magna

Faculty Mentor Information

Dr. Leigh C. Latta

Abstract

Protein aggregates are associated with various age-related pathologies of the nervous system, such as Huntington’s disease and Alzheimer’s disease in humans. This research examines the extent to which spontaneous mutations may exacerbate age-related changes in the accumulation of protein aggregates in the model organism Daphnia magna. Protein aggregates in young and old mutant and non-mutant lines of Daphnia are quantified fluorometrically, and then the age-related patterns of protein aggregation are compared between the four groups.

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The Effect of Mutation on Age-Related Changes in Protein Aggregation in Daphnia magna

Protein aggregates are associated with various age-related pathologies of the nervous system, such as Huntington’s disease and Alzheimer’s disease in humans. This research examines the extent to which spontaneous mutations may exacerbate age-related changes in the accumulation of protein aggregates in the model organism Daphnia magna. Protein aggregates in young and old mutant and non-mutant lines of Daphnia are quantified fluorometrically, and then the age-related patterns of protein aggregation are compared between the four groups.