2026 Undergraduate Research Showcase

Investigations on the Interaction of PCB72 with Bilayer Lipid Membranes

Document Type

Student Presentation

Presentation Date

4-24-2026

Faculty Sponsor

Dr. Daniel Fologea

Abstract

This study investigates the molecular effects of the persistent organic pollutant PCB72 on lipid membrane fluidity and transport properties. Polychlorinated biphenyls (PCBs), classified as "forever chemicals," pose significant health risks due to their bioaccumulation and toxicity, yet their interactions with cellular membranes remain poorly understood. We hypothesize that lipid membranes are primary targets of PCB72, with its incorporation altering membrane biophysical properties and cellular function. To test this, we employ an experimental bilayer lipid membrane (BLM) system subjected to controlled hydrostatic pressure to induce curvature, allowing assessment of membrane fluidity through electrophysiological measurements. Comparisons are made between cholesterol-free, cholesterol-containing, and PCB72-exposed membranes. Results demonstrate that PCB72 significantly increases both capacitance and ionic conductance, which we interpreted as an increased membrane fluidity and permeability. Notably, these effects closely resemble those induced by cholesterol, suggesting that PCB72 integrates into the lipid bilayer and modifies its mechanical and transport properties. This work offers insights into how organic environmental pollutants may compromise cell integrity, with broad implications for toxicology and human health.

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