2026 Undergraduate Research Showcase

Assessing Plasma Stability of 7-Hydroxymitragynine Found in Kratom

Document Type

Student Presentation

Presentation Date

4-24-2026

Faculty Sponsor

Dr. Owen McDougal and Anna Shuey

Abstract

Kratom is an herbal supplement derived from the leaves of the tropical evergreen Mitragyna Speciosa. The U.S consumption of kratom has increased significantly, reaching millions of users. This popularity is attributed to its dose-dependent effects: low doses elicit excitatory effects, while high doses induce sedation similar to opiates. These effects are primarily attributed to alkaloids 7-hydroxymitragynine (7-HMG) and mitragynine (MG), although over 40 have been identified. Individuals addicted to opioids who can no longer obtain them through a physician, are increasingly consuming kratom as a perceived safer and natural alternative. Despite being marketed in the U.S as a safe alternative to traditional medicine, kratom use is perilous, resulting in adverse events – including death – especially in poly-substance use with opioids or benzodiazepines. There is a critical need to better understand the pharmacokinetic properties of understudied alkaloids in comparison to 7-HMG and MG. We aim to contribute to this gap in knowledge using in vitro assays, including plasma stability. Plasma stability will indicate how long the alkaloids can exist in human plasma before being degraded. Plasma stability for 7-Hydroxymitragynine has been researched, and data for the other alkaloids needs to be collected. As the pharmacokinetic properties of these alkaloids become better understood, regulatory bodies will have data to inform consumer safety for this currently unregulated and widely available product.

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