Cardiotoxicity has been associated with various types of chemotherapeutic drugs contributing to a plethora of cardiac insults and is a significant side effect when treating cancer. Many highly effective anticancer drugs are severely dose dependent, and at higher doses can lead to: cardiac arrhythmias, hypertension, and lethal cardiomyopathy. A well known example of this cardiotoxic side effect is Doxorubicin, a common chemotherapeutic used to treat cancers of the breast, ovary, bladder, and thyroid. Extensive research has shown that high doses of doxorubicin detrimentally alters the normal function of cardiac fibroblasts and cardiomyocytes. In contrast to the extensive research on the toxic effects of chemotherapeutics like doxorubicin in cardiomyocytes, little is known on the effects in cardiac fibroblasts and mechanisms of these drugs on the cardiac extracellular matrix (cECM). We show that doxorubicin has a direct impact on cardiac fibroblasts and in turn the function of the cECM, indicating that the cECM plays an important role in cardiac toxicity induced by doxorubicin.
Lantz, Tyler; Patricelli, Conner; Nick, Steve; Turner, Matthew; Oxford, Julia; and Pu, Xinzhu, "Effects of Doxorubicin on Cardiac Fibroblasts and the Extracellular Matrix" (2021). 2021 Undergraduate Research Showcase. 40.