The Effect of Nerve Growth Factor on Neurite Extensions in Rat Pheochromocytoma, Pc12, Cells
College of Arts and Sciences
The rat pheochromocytoma cell line, AKA PC12, is a model cell line used to investigate neuronal differentiation. PC12 cells respond to nerve growth factor (NGF) by generating dendritic extensions, which are a typical phenotype of neuronal cells. A fundamental understanding and characterization of neural response to NGF is essential to developing this cell line as a model system for our studies of the impact of extracellular matrix molecules. Here, we have quantified neurite behaviors of PC12 cells in serum rich, serum starved and serum starved with NGF media up to 168 hours.
Titmus, J. T., "The Effect of Nerve Growth Factor on Neurite Extensions in Rat Pheochromocytoma, Pc12, Cells" (2018). 2018 Undergraduate Research and Scholarship Conference. 85.