The Impacts of Mechanical and Electrical Stimulation on Mesenchymal Stem Cell Proliferation and Differentiation
College of Engineering
Mechanical and Biomedical Engineering
Graphene, a material made up of a single layer of carbon atoms arranged into a honeycomb lattice, is a promising candidate for biosensors and bioscaffolds due to is mechanical and electrical properties. Recent studies show graphene is biocompatible and promotes the proliferation and differentiation of stem cells. However, few studies have investigated the structure-property-processing correlations of graphene bioscaffolds, as well as the impact of external stimuli applied to graphene bioscaffolds on the stem cell growth and differentiation. This study will use chemical vapour deposition to synthesize graphene foam - a 3D polymorph of graphene - and apply both electrical and mechanical stimuli to the scaffold to investigate the impact of such scaffolds and stimulus on the growth and differentiation of mesenchymal stem cells. These stem cells will be analyzed both qualitatively and quantitatively to observe the effects the graphene foam stimulation has on the MSCs morphology and gene expression.
Howard, Vanessa, "The Impacts of Mechanical and Electrical Stimulation on Mesenchymal Stem Cell Proliferation and Differentiation" (2018). 2018 Undergraduate Research and Scholarship Conference. 53.