College of Arts and Sciences
We investigated a model system for cardiac fibrosis. Cardiac fibrosis is the thickening of the heart wall due to the inappropriate proliferation of cardiac fibroblasts and excess deposition of extracellular matrix in the cardiac muscle.
To understand how the cells, respond to stress, we analyzed changes in gene expression. Our research imitated the stress conditions that the heart cells experience. We chose to analyze genes that have not previously been characterized under uniaxial, biaxial and stress-free environments to look at how gene expression varies under different conditions. We normalized all data to a validated housekeeping genes.
This research will help people with various heart problems in repairing damaged tissue. We expect to increase the understanding of the cause of cardiac fibrosis and contribute to a solution. Our conclusions will compare gene expression during healthy conditions to damage repair conditions.
Mosqueda, Elizabeth; Schroeder, Jericho; Small, Dana; Dodge, Caitlyn; Frahs, Stephanie; and Oxford, Julia, "Manipulating Fibroblast Environment to Study Specific Gene Expression" (2018). 2018 Undergraduate Research and Scholarship Conference. 101.