Publication Date

5-2024

Date of Final Oral Examination (Defense)

November 2023

Type of Culminating Activity

Thesis

Degree Title

Master of Science in Mechanical Engineering

Department Filter

Mechanical and Biomechanical Engineering

Department

Mechanical and Biomedical Engineering

Supervisory Committee Chair

Gunes Uzer, Ph.D.

Supervisory Committee Co-Chair

Aykut Satici, Ph.D.

Supervisory Committee Member

Zhangxian Deng, Ph.D.

Abstract

The advent of extended-duration human spaceflight demands a better comprehension of the physiological impacts of microgravity. One primary concern is the adverse impact on the musculoskeletal system, including muscle atrophy and bone density reduction. Ground-based microgravity simulations have provided insights, with vibrational bioreactors emerging as potential mitigators of these negative effects. Despite the potential they have, the adaptation of vibrational bioreactors for space remains unfulfilled, resulting in a significant gap in microgravity research. This paper introduces the first automated low-intensity vibrational (LIV) bioreactor designed specifically for the International Space Station (ISS) environment. Our research covers the bioreactor's design and characterization, the selection of an optimal linear guide for consistent 1-axis acceleration, a thorough analysis of its thermal and diffusion dynamics, and the pioneering use of BioMed Clear resin for enhanced scaffold design. This advancement sets the stage for more authentic space-based biological studies, vital for ensuring the safety of future space explorations.

DOI

https://doi.org/10.18122/td.2176.boisestate

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