Publication Date
8-2021
Date of Final Oral Examination (Defense)
6-30-2021
Type of Culminating Activity
Dissertation
Degree Title
Doctor of Philosophy in Biomolecular Sciences
Department
Biology
Major Advisor
Julia T. Oxford, Ph.D.
Advisor
Matthew Ferguson, Ph.D.
Advisor
Brad Morrison, Ph.D.
Advisor
Allan Albig, Ph.D.
Abstract
The ear is essential to maintaining balance and hearing; both of which can be linked to one another and significantly impact a person’s quality of life. Although aging and damage are more common reasons for hearing loss, congenital ear defects still have a considerable impact on our population. The function of the ear can be affected by structural deformities to the ear and its components which results in hearing loss. Mutations and single nucleotide polymorphisms in the gene encoding Collagen XI alpha one chain (COL11A1) protein can play a role in hearing and balance dysfunction in humans as seen in disorders such as Stickler Type 2 and Marshall Syndrome, and nonsyndromic hearing loss deafness autosomal dominant 37 (DFNA37). Due to its transparency, external fertilization, the zebrafish model system was used to create a COL11A1 zebrafish counterpart (Col11a1a) knockdown and knockout genetic model. This research highlights the importance of Col11a1a in the development and structure of the inner ear as a whole including the hair cells, kinocilia, and otolith formation. Studying the development and structural changes of the inner ear can provide insight into hearing loss and potential interventions.
DOI
https://doi.org/10.18122/td.1864.boisestate
Recommended Citation
Hardy, Makenna, "Collagen XI Impact on Structure and Function of the Vertebrate Inner Ear in a Zebrafish Model" (2021). Boise State University Theses and Dissertations. 1864.
https://doi.org/10.18122/td.1864.boisestate