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Document Type

Abstract

Publication Date

1-14-2026

Abstract

In this study, solitary nursing and chronic unpredictable mild stress (CUMS) were used to establish a depressed rat model. The influence of aerobic exercise on the fatigue of depressed animals provides experimental reference for the practice of exercise therapy for depression. The purpose of this study was to establish a CUMS depressed rat model. The aerobic exercise intervention was carried out on the depressed rats on a rotating treadmill. Method: Behavioral tests, such as body weight and sugar, and water preference, were conducted to verify the establishment of the depression model and the antidepressant effect of aerobic exercise. Biochemical fatigue, such as blood ammonia, corticosterone, and testosterone, was determined, and correlation analysis of “behavioral indexes- fatigue indexes” in depressed rats was conducted. After three weeks of modeling, compared with normal rats, the body weight, sugar water preference, and other indicators of depressed rats were significantly decreased (p < 0.05 or p < 0.01), indicating that the depression modeling was successful. After four depression significantly reduced (p < 0.05 or p < 0.01), indicating that aerobic exercise has a good anti-depression effect. Correlation analysis showed that there was significant correlation between serum ammonia, testosterone, and corticosterone fatigue in behavioral indexes in depressed rats (r>0.5 and p < 0.05). Aerobic exercise can significantly improve depressive behavior in stressed rats, and the combination of fatigue and behavioral inhibition can enrich the evaluation content of exercise therapy for depression.

DOI

https://doi.org/10.18122/ijpah.5.1.84.boisestate

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