Abstract Title

Synthesis and Antibacterial Properties of ZnO Nanoparticles from Hydrastis canadensis Extract

Additional Funding Sources

The project described was supported by an Institutional Development Award (IDeA) from the National Institute of General Medical Sciences of the National Institutes of Health under Grant No. P20GM103408.

Abstract

Zinc oxide nanoparticles (ZnO NPs) have become a popular metal oxide nanoparticle for uses in biomedical applications due to their antibacterial properties. ZnO NPs, when capped with natural products from plant extracts with known antibacterial properties, are hypothesized to cause bacterial stasis and have enhanced bactericidal performance. This project focuses on synthesizing and characterizing ZnO NPs capped with molecules extracted from goldenseal root (Hydrastis canadensis) and testing their antibacterial properties against Escherichia coli and Staphylococcus aureus. The ZnO NPs were synthesized using zinc nitrate hexahydrate and aqueous extracts from Hydrastis canadensis. The ZnO NPs were prepared by alkali precipitation from an aqueous solution at 65°C and characterized by infrared (FTIR) spectroscopy and thermogravimetric analysis. The antibacterial properties were evaluated using disk diffusion and bacteria growth experiments.

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Synthesis and Antibacterial Properties of ZnO Nanoparticles from Hydrastis canadensis Extract

Zinc oxide nanoparticles (ZnO NPs) have become a popular metal oxide nanoparticle for uses in biomedical applications due to their antibacterial properties. ZnO NPs, when capped with natural products from plant extracts with known antibacterial properties, are hypothesized to cause bacterial stasis and have enhanced bactericidal performance. This project focuses on synthesizing and characterizing ZnO NPs capped with molecules extracted from goldenseal root (Hydrastis canadensis) and testing their antibacterial properties against Escherichia coli and Staphylococcus aureus. The ZnO NPs were synthesized using zinc nitrate hexahydrate and aqueous extracts from Hydrastis canadensis. The ZnO NPs were prepared by alkali precipitation from an aqueous solution at 65°C and characterized by infrared (FTIR) spectroscopy and thermogravimetric analysis. The antibacterial properties were evaluated using disk diffusion and bacteria growth experiments.