Abstract Title

Biological Comparison Between Healthy, Aged and Worn Knee Cartilage

Additional Funding Sources

The project described was supported by Institutional Development Awards (IDeA) from the National Institute of General Medical Sciences of the National Institutes of Health under Grant Nos. P20GM103408 and P20GM109095, and National Science Foundation S-STEM Gateway Scholarships in Biological Sciences under Grant Award No. DUE-1644233. We also acknowledge support from the Biomolecular Research Center at Boise State with funding from the National Science Foundation, Grant Nos. 0619793 and 0923535, the M.J. Murdock Charitable Trust, and the Idaho State Board of Education. Additional supported was received via an Institutional Development Award (IDeA) from the National Institute of General Medical Sciences of the National Institutes of Health under Grant No. P20GM103408.

Abstract

Knowledge of cartilage composition and structure in the knee is essential to understanding how the joint will be affected by mechanical loading. Biological, structural, and mechanical factors all play a role in determining how susceptible the knee may be to osteoarthritis and joint degeneration. The purpose of this study is to compare healthy cartilage, aged and worn cartilage that has recently undergone 1 M gait loading cycles. The importance of this research is to improve productivity and quality of life for patients at risk of osteoarthritis to minimize severe pain and stress on the knee. This approach has been used in our lab to investigate the comparison of the three different types of cartilage.

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Biological Comparison Between Healthy, Aged and Worn Knee Cartilage

Knowledge of cartilage composition and structure in the knee is essential to understanding how the joint will be affected by mechanical loading. Biological, structural, and mechanical factors all play a role in determining how susceptible the knee may be to osteoarthritis and joint degeneration. The purpose of this study is to compare healthy cartilage, aged and worn cartilage that has recently undergone 1 M gait loading cycles. The importance of this research is to improve productivity and quality of life for patients at risk of osteoarthritis to minimize severe pain and stress on the knee. This approach has been used in our lab to investigate the comparison of the three different types of cartilage.