Magnetic Shape Memory Alloy Micro-pump for Sub-microliter Intracranial Drug Delivery
Magnetic shape-memory alloys exhibit strong magneto-structural coupling enabling large magnetic-field-induced deformation. Local control of twinning via variable inhomogeneous magnetic fields initiates local reversible deformation. We applied this concept to build a valve-less micro-pump consisting of a Ni-Mn-Ga single crystal, a casing, and a rod magnet. The micro-pump successfully pumped fluid in opposite directions when the magnet was turned clockwise and counter clockwise. Here, we modify this micro-pump for application on a rat, which would simultaneously monitor electroencephalograph data and deliver 0.5-5.0 μl of a drug solution at 100-500 nl/min directly to the rat’s brain. We used a prototype of this pump at Birmingham University, U.K. where it was implemented in live experiments. The pump successfully delivered intracranial drug dosages at sub-microliter per minute rates through several trials.
Barker, Sam; Rhoads, Eric; Lindquist, Paul; and Vreugdenhil, Martin, "Magnetic Shape Memory Alloy Micro-pump for Sub-microliter Intracranial Drug Delivery" (2015). College of Engineering Presentations. 18.