1 00:00:00,000 --> 00:00:03,100 - Up next we have Brie Ellison 2 00:00:03,100 --> 00:00:06,766 from Interdisciplinary Studies with a talk titled, 3 00:00:06,766 --> 00:00:09,799 “Challenges and Opportunities in Human Subjects Research: 4 00:00:09,800 --> 00:00:14,533 “Assessing Glyphosate Exposure in Pregnant Women.” 5 00:00:14,533 --> 00:00:17,799 Brie, take it away. 6 00:00:17,800 --> 00:00:19,500 - Good morning, everyone. 7 00:00:19,500 --> 00:00:23,333 Many of you are probably familiar with weed killers like RoundUp, 8 00:00:23,333 --> 00:00:26,866 a common herbicide that my own parents used on their farm. 9 00:00:26,866 --> 00:00:30,166 Glyphosate is the main ingredient in products like RoundUp, 10 00:00:30,166 --> 00:00:36,032 and its usage rose 1200% worldwide in the last two decades. 11 00:00:36,033 --> 00:00:41,266 It's great at destroying weeds, but what's it doing to our health? 12 00:00:41,266 --> 00:00:43,066 A few previous studies have suggested 13 00:00:43,066 --> 00:00:47,766 that glyphosate exposure during pregnancy may lead to preterm birth, 14 00:00:47,766 --> 00:00:51,166 but much more research is needed to understand if this is true 15 00:00:51,166 --> 00:00:53,932 and how exposure is occurring. 16 00:00:53,933 --> 00:00:58,466 We designed a robust study to follow 40 women throughout pregnancy, 17 00:00:58,466 --> 00:01:01,566 collecting weekly, and sometimes daily, 18 00:01:01,566 --> 00:01:04,932 urine samples during a two-week dietary intervention, 19 00:01:04,933 --> 00:01:10,199 to compare glyphosate levels when eating organically versus conventionally. 20 00:01:10,200 --> 00:01:12,900 We are currently awaiting results from the CDC 21 00:01:12,900 --> 00:01:15,300 regarding the glyphosate measurements. 22 00:01:15,300 --> 00:01:17,700 In the meantime, I'd like to share our discoveries 23 00:01:17,700 --> 00:01:19,500 about human subjects research, 24 00:01:19,500 --> 00:01:23,566 and how we were successful despite many challenges. 25 00:01:23,566 --> 00:01:26,499 One of the challenges was the COVID-19 pandemic. 26 00:01:26,500 --> 00:01:30,700 Recruitment and informed consent is a vital step in human subjects research, 27 00:01:30,700 --> 00:01:33,033 and it's typically done in-person. 28 00:01:33,033 --> 00:01:37,899 Instead, we created YouTube videos to better connect with the participants. 29 00:01:37,900 --> 00:01:39,633 We would park outside their house, 30 00:01:39,633 --> 00:01:41,233 drop the forms on the doorstep, 31 00:01:41,233 --> 00:01:42,699 send them links to the videos, 32 00:01:42,700 --> 00:01:45,300 and phone them to go over the paperwork. 33 00:01:45,300 --> 00:01:47,000 Then, we would drop off the urine cup 34 00:01:47,000 --> 00:01:50,900 and pick it up when it was filled, all in real time. 35 00:01:50,900 --> 00:01:53,266 That allowed us to maintain social distancing, 36 00:01:53,266 --> 00:01:55,499 but keep a more personal feel, 37 00:01:55,500 --> 00:01:59,933 which ended up being a key part of our success in participant retention. 38 00:01:59,933 --> 00:02:04,266 And participant retention was a major concern throughout our study. 39 00:02:04,266 --> 00:02:05,799 We had to keep the women engaged 40 00:02:05,800 --> 00:02:08,566 on a weekly and sometimes daily basis 41 00:02:08,566 --> 00:02:13,366 to get the kind of in-depth data that's missing from this area of research. 42 00:02:13,366 --> 00:02:16,599 On top of that, many of the women were dealing with difficulties 43 00:02:16,600 --> 00:02:18,900 that impacted their availability. 44 00:02:18,900 --> 00:02:23,533 One of our participants was homeless for the duration of the study. 45 00:02:23,533 --> 00:02:26,666 I once had to pick up a sample outside a Hobby Lobby. 46 00:02:26,666 --> 00:02:29,066 Many of them dealt with food and housing insecurity, 47 00:02:29,066 --> 00:02:32,799 irregular job schedules, and children with disabilities. 48 00:02:32,800 --> 00:02:34,400 But despite these challenges, 49 00:02:34,400 --> 00:02:39,366 we collected 1,395 samples from 40 women 50 00:02:39,366 --> 00:02:40,999 over a nine month period, 51 00:02:41,000 --> 00:02:43,766 for a 97% compliance rate. 52 00:02:43,766 --> 00:02:45,232 How do we do it? 53 00:02:45,233 --> 00:02:48,399 By building a personal connection with these women. 54 00:02:48,400 --> 00:02:49,933 In research, it's easy to say 55 00:02:49,933 --> 00:02:54,033 that we give back to our participants retroactively, through results. 56 00:02:54,033 --> 00:02:57,266 But through our study, we were able to immediately impact these women 57 00:02:57,266 --> 00:02:59,932 and help improve their quality of life. 58 00:02:59,933 --> 00:03:01,733 We built personal connections, 59 00:03:01,733 --> 00:03:03,566 we texted them updates and reminders, 60 00:03:03,566 --> 00:03:05,099 compensated them with gift cards, 61 00:03:05,100 --> 00:03:09,633 and provided each with $360 in groceries. 62 00:03:09,633 --> 00:03:12,466 We knew them by name, knew what they were dealing with, 63 00:03:12,466 --> 00:03:16,799 and worked with their unique situations as much as possible. 64 00:03:16,800 --> 00:03:19,700 Throughout the study, we had many women express their gratitude 65 00:03:19,700 --> 00:03:21,266 for the help we provided them, 66 00:03:21,266 --> 00:03:23,932 as well as excitement for our research. 67 00:03:23,933 --> 00:03:24,799 If you'd like to hear more 68 00:03:24,800 --> 00:03:27,700 about this important stepping stone in glyphosate research, 69 00:03:27,700 --> 00:03:31,000 please feel free to check out my poster and ask me any questions.