The evolution of multicellular metazoan organisms was marked by the inclusion of an extracellular matrix (ECM), a multicomponent, proteinaceous network between cells that contributes to the spatial arrangement of cells and the resulting tissue organization. The development of an ECM that provides support in larger organisms may have represented an advantage in the face of selection pressure for the evolution of the ECM.
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Oxford, Julia Thom; Reeck, Jonathon C.; and Hardy, Makenna J.. (2019). "Extracellular Matrix in Development and Disease". International Journal of Molecular Sciences, 20(1), 205-1 - 205-5.