Emerging Genetic Basis of Osteochondritis Dissecans

Authors

J. Tyler Bates, Boise State University
John C. Jacobs Jr., University of Utah
Kevin G. Shea, St. Luke’s Sports Medicine
Julia Thom Oxford, Boise State UniversityFollow

Document Type

Article

Publication Date

4-2014

DOI

http://dx.doi.org/10.1016/j.csm.2013.11.004

Abstract

Osteochondritis dissecans (OCD) is a focal idiopathic alteration of subchondral bone with risk for instability and disruption of adjacent articular cartilage that may result in premature osteoarthritis (OA).¹ This condition is commonly found in horses, pigs, dogs, and humans². König³ first used the term OCD to describe a condition that causes the formation of loose bodies in the joints of young individuals without arthritis or trauma. Although more than 100 years have passed since König³ described OCD, little knowledge exists of the specific etiology and pathogenesis of this disease. Many etiologic theories have been proposed for the onset and progression of OCD, including trauma, diet, rapid growth, anatomic characteristics, lack of blood supply, necrosis of subchondral bone, and heredity (recently reviewed in Refs. ^4-8). Recent experiments have provided additional information regarding the underlying genetic traits that may predispose an individual to OCD.

Publication Information

Bates, J. Tyler; Jacobs, John C. Jr.; Shea, Kevin G.; and Oxford, Julia Thom. (2014). "Emerging Genetic Basis of Osteochondritis Dissecans". Clinics in Sports Medicine, 33(2), 199-220.