Characterization of Basement Membrane Induced Endothelial Cell Quiescence in the Presence of Growth factors
The importance of the basement membrane (BM) in endothelial cells' (ECs) response to growth factors (GF) during angiogenesis is not well characterized. This is in part due to the lack of laboratory models which accurately replicate the angiogenic conditions experienced inside of tissues. We hypothesize that the degradation of the BM is required for ECs to respond to GF signaling. We propose to address this hypothesis with two specific aims: to develop a model that accurately portrays angiogenic signals in capillaries, and to determine if ECs will respond to GF signaling in the presence of BM.
DeFord, Peter, "Characterization of Basement Membrane Induced Endothelial Cell Quiescence in the Presence of Growth factors" (2014). College of Arts and Sciences Presentations. 52.