BMP-1 Mediated Proteolytic Processing of Alternatively Spliced Isoforms of Collagen Type XI

Publication Date


Type of Culminating Activity


Degree Title

Master of Science in Biology



Major Advisor

Julia Thom Oxford


Collagen type XI is a component of the extracellular fibrillar network of embryonic cartilage. Collagen type XI belongs to the family of fibrillar collagens, which includes types I, II, III, V, and XI (Yoshioka, H., Ramirez, F., 1990). Collagen type XI plays a role in the assembly of embryonic cartilage collagen fibrils, as the diameter of cartilage collagen fibrils is dependent on the relative ratio of collagen types II and XI (Eikenberry, E. F., Mendler, M., Burgin, R., Winterhalter, K. H., Bruckner, P., 1982). Collagen type XI is involved in the establishment and maintenance of healthy cartilage, is essential for the correct structure of the cartilage extracellular matrix to form, and for skeletal morphogenesis and growth. The work presented in this thesis significantly advances the current understanding of the biology of collagen type XI, a key component of cartilage, and provides new information about the function of the isoforms.

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