Synthesis of Calixarene Through Sonication
Abstract
Synthesis of Calixarene Through Sonication: Supramolecular calixarenes are unique formations of hexameric “nano-capsules”, able to hold or capture other molecules. This distinctive ability may be implemented in the design of catalysts, developing new materials, and creating new methods for pharmaceutical delivery. Specifically, we will explore the synthesis of isobutyl-calix[4]pyrogallolarenes through an acid catalyzed condensation reaction driven by sonication, a technique in which bubbles of extreme pressure and temperatures are created within the reaction vessel. While other studies have explored many solvent-free syntheses and microwave technology, sonication is unexplored. By varying the power output and length of sonication, we will be able study the relationships between processing conditions and product stereochemistry. Other variables include control of the temperature before, during and after the reaction, as well as the comparing the effectiveness of hydrochloric, trifluoroacetic, trifluoromethanesulfonic, and para-toluenesulfonic acid catalysts.
Synthesis of Calixarene Through Sonication
Synthesis of Calixarene Through Sonication: Supramolecular calixarenes are unique formations of hexameric “nano-capsules”, able to hold or capture other molecules. This distinctive ability may be implemented in the design of catalysts, developing new materials, and creating new methods for pharmaceutical delivery. Specifically, we will explore the synthesis of isobutyl-calix[4]pyrogallolarenes through an acid catalyzed condensation reaction driven by sonication, a technique in which bubbles of extreme pressure and temperatures are created within the reaction vessel. While other studies have explored many solvent-free syntheses and microwave technology, sonication is unexplored. By varying the power output and length of sonication, we will be able study the relationships between processing conditions and product stereochemistry. Other variables include control of the temperature before, during and after the reaction, as well as the comparing the effectiveness of hydrochloric, trifluoroacetic, trifluoromethanesulfonic, and para-toluenesulfonic acid catalysts.