DNA Topology Influences Molecular Machine Lifetime in Human Serum

Authors

Sara Goltry, Boise State University
Natalya Hallstrom, Boise State UniversityFollow
Tyler Clark, Boise State University
Wan Kuang, Boise State UniversityFollow
Jeunghoon Lee, Boise State UniversityFollow
Cheryl Jorcyk, Boise State UniversityFollow
William B. Knowlton, Boise State UniversityFollow
Bernard Yurke, Boise State UniversityFollow
William L. Hughes, Boise State UniversityFollow
Elton Graugnard, Boise State UniversityFollow

Document Type

Article

Publication Date

6-21-2015

DOI

http://dx.doi.org/10.1039/C5NR02283E

Abstract

DNA nanotechnology holds the potential for enabling new tools for biomedical engineering, including diagnosis, prognosis, and therapeutics. However, applications for DNA devices are thought to be limited by rapid enzymatic degradation in serum and blood. Here, we demonstrate that a key aspect of DNA nanotechnology—programmable molecular shape—plays a substantial role in device lifetimes. These results establish the ability to operate synthetic DNA devices in the presence of endogenous enzymes and challenge the textbook view of near instantaneous degradation.

Comments

For complete list of authors, please see article.

Copyright Statement

This document was originally published by Royal Society of Chemistry Publishing in Nanoscale. This work is provided under Creative Commons Attribution License 3.0. Details regarding the use of this work can be found at: http://creativecommons.org/licenses/by/3.0/. doi: 10.1039/C5NR02283E

Publication Information

Goltry, Sara; Hallstrom, Natalya; Clark, Tyler; Kuang, Wan; Lee, Jeunghoon; Jorcyk, Cheryl; Knowlton, William B.; Yurke, Bernard; Hughes, William L.; and Graugnard, Elton. (2015). "DNA Topology Influences Molecular Machine Lifetime in Human Serum". Nanoscale, 7(23), 10382-10390.